Lasix (Furosemide) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Adverse reactions are categorized below by organ system and listed by decreasing severity.

Gastrointestinal System Reactions

1. hepatic encephalopathy in patients with hepatocellular insufficiency
2. pancreatitis
3. jaundice (intrahepatic cholestatic jaundice)
4. anorexia
5. oral and gastric irritation
6. cramping
7. diarrhea
8. constipation
9. nausea
10. vomiting

Systemic Hypersensitivity Reactions

1. systemic vasculitis
2. interstitial nephritis
3. necrotizing angiitis

Central Nervous System Reactions

1. tinnitus and hearing loss
2. paresthesias
3. vertigo
4. dizziness
5. headache
6. blurred vision
7. xanthopsia

Hematologic Reactions

1. aplastic anemia (rare)
2. thrombocytopenia
3. agranulocytosis (rare)
4. hemolytic anemia
5. leukopenia
6. anemia

Dermatologic-Hypersensitivity Reactions

1. exfoliative dermatitis
2. bullous pemphigoid
3. erythema multiforme
4. purpura
5. photosensitivity
6. urticaria
7. rash
8. pruritus

Cardiovascular Reaction

Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates or narcotics.

Other Reactions

1. hyperglycemia
2. glycosuria
3. hyperuricemia
4. muscle spasm
5. weakness
6. restlessness
7. urinary bladder spasm
8. thrombophlebitis
9. fever

Whenever adverse reactions are moderate or severe, LASIX dosage should be reduced or therapy withdrawn.



REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO LASIX

Below is a sample of reports where side effects / adverse reactions may be related to Lasix. The information is not vetted and should not be cosidered as verified clinical evidence.

Possible Lasix side effects / adverse reactions in 79 year old male

Reported by a physician from Japan on 2007-01-12

Patient: 79 year old male weighing 38.0 kg (83.6 pounds)

Reactions: Anorexia, Dehydration, NO Therapeutic Response, Depressed Level of Consciousness, Atrial Fibrillation, Sinus Arrest, Arrhythmia

Adverse event resulted in: death

Suspect drug(s):
Lasix
Administration route: Oral
Indication: Cardiac Failure Chronic
Start date: 2006-11-28
End date: 2006-12-17

Ancaron
Administration route: Oral
Indication: Atrial Fibrillation
Start date: 2006-12-07
End date: 2006-12-12

Ancaron
Administration route: Oral
Start date: 2006-12-13
End date: 2006-12-17

Longes
Administration route: Oral
Indication: Cardiac Failure Chronic
Start date: 2006-11-28
End date: 2006-12-17

Aldactazide-A
Administration route: Oral
Indication: Cardiac Failure Chronic
Start date: 2006-11-28
End date: 2006-12-17

Other drugs received by patient: Warfarin Sodium; Aspirin; Aspirin

Possible Lasix side effects / adverse reactions in 73 year old male

Reported by a health professional (non-physician/pharmacist) from Sweden on 2007-01-12

Patient: 73 year old male

Reactions: Gastrointestinal Haemorrhage, Syncope, Anaemia, Blood Creatinine Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
Atacand HCT
Administration route: Oral
Indication: Essential Hypertension

Lasix
Administration route: Oral

Trombyl 160 MG
Administration route: Oral

Metformin
Administration route: Oral
Indication: Diabetes Mellitus

Glibenklamid Recip 1,75 MG
Administration route: Oral
Indication: Diabetes Mellitus

Diclofenac Sodium
Indication: Gout

Other drugs received by patient: Folacin 5 MG; Behepan 1 MG; Lansoprazole

Possible Lasix side effects / adverse reactions in 84 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2007-01-12

Patient: 84 year old male

Reactions: Subdural Haematoma, International Normalised Ratio Increased, Fall, Haematoma

Adverse event resulted in: hospitalization

Suspect drug(s):
Amlor
Administration route: Oral

Perindopril Erbumine
Administration route: Oral

Previscan
Administration route: Oral
Indication: Atrial Flutter

Glucophage
Administration route: Oral

Lasix
Administration route: Oral


Possible Lasix side effects / adverse reactions in 91 year old female

Reported by a individual with unspecified qualification from France on 2007-01-16

Patient: 91 year old female

Reactions: Right Ventricular Failure, Bedridden, Hyperkalaemia, Lung Infection, Atrioventricular Block Complete, Cachexia, Renal Failure, Decubitus Ulcer, Hypoxia, Hyperthyroidism

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Cordarone
Dosage: 200 mg 1x per 1 day
Administration route: Oral
Indication: Atrial Fibrillation

Cordarone
Dosage: 200 mg 1x per 1 day
Administration route: Oral
Indication: Atrial Flutter

Perindopril Erbumine
Administration route: Oral
Indication: Essential Hypertension
End date: 2006-10-18

Lasix
Dosage: 40 mg 1x per 1 day
Administration route: Oral
End date: 2006-10-18

Voltaren
Dosage: 75 mg 1x per 1 day
Administration route: Oral
Indication: Rheumatoid Arthritis
End date: 2006-10-18

Other drugs received by patient: Stablon (Tianeptine); Depakene; Amlodipine Besylate

Possible Lasix side effects / adverse reactions in 76 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2007-01-16

Patient: 76 year old female weighing 70.0 kg (154.0 pounds)

Reactions: Pruritus, Rash Erythematous, Rash Maculo-Papular

Adverse event resulted in: hospitalization

Suspect drug(s):
Aldactone
Dosage: daily dose:25mg
Administration route: Oral
Start date: 2006-08-31
End date: 2006-09-13

Lasix
Administration route: Oral
Start date: 2006-07-20
End date: 2006-09-16

Triatec
Administration route: Oral
Start date: 2006-07-27
End date: 2006-09-13

Previscan
Administration route: Oral

Cordarone
Administration route: Oral
Start date: 2006-08-24
End date: 2006-09-13

Diffu K
Administration route: Oral
Start date: 2006-08-31
End date: 2006-09-16


Possible Lasix side effects / adverse reactions in 65 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2007-01-16

Patient: 65 year old female

Reactions: Pemphigoid, Stevens-Johnson Syndrome

Suspect drug(s):
Lasix
Administration route: Oral
End date: 2006-12-14

BI Sifrol
Start date: 2006-12-08
End date: 2006-12-14

Other drugs received by patient: Gramalil; Luprac

Possible Lasix side effects / adverse reactions in 74 year old female

Reported by a individual with unspecified qualification on 2007-01-16

Patient: 74 year old female

Reactions: Pruritus, Rash Erythematous, Eczema

Adverse event resulted in: hospitalization

Suspect drug(s):
Lasix
Administration route: Oral

Cordarone
Administration route: Oral

Allopurinol TAB
Administration route: Oral
Start date: 2006-06-01
End date: 2006-09-22

Nebcin
Start date: 2006-07-10
End date: 2006-07-12

Previscan /00789001/
Administration route: Oral

Gentamicin
Start date: 2006-07-13
End date: 2006-07-15

Other drugs received by patient: Aldactone; Adancor; Corvasal /00547101/; Imovane; Nexium; Serevent; Mixtard /00634701/

Possible Lasix side effects / adverse reactions in 91 year old female

Reported by a individual with unspecified qualification from France on 2007-01-16

Patient: 91 year old female

Reactions: Escherichia Urinary Tract Infection, Hyperkalaemia, Pain, Failure TO Thrive, C-Reactive Protein Increased, Decubitus Ulcer, Oedema Peripheral, Pulmonary Congestion, Hypoxia, Renal Failure Acute, White Blood Cell Count Increased, Dyspnoea, General Physical Health Deterioration, Physiotherapy Chest, Brain Natriuretic Peptide Increased, Cardiac Failure, Bronchitis, Asthenia

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Voltarene LP
Dosage: 75 mg, qd
Administration route: Oral
Indication: Rheumatoid Arthritis
End date: 2006-10-18

Perindopril Erbumine
Administration route: Oral
Indication: Essential Hypertension
End date: 2006-10-18

Lasix
Dosage: 40 mg, qd
Administration route: Oral
End date: 2006-10-18

Cordarone
Dosage: 200 mg, qd
Administration route: Oral
Indication: Atrial Fibrillation
End date: 2006-10-18

Other drugs received by patient: Depakene; Amlor; Stablon

Possible Lasix side effects / adverse reactions in 72 year old female

Reported by a physician from France on 2007-01-17

Patient: 72 year old female

Reactions: Malaise, Hypoglycaemia, Renal Failure Acute

Adverse event resulted in: hospitalization

Suspect drug(s):
Acarbose
Dosage: total daily dose: 150 mg unit dose: 50 mg
Administration route: Oral
Indication: Diabetes Mellitus
End date: 2006-07-07

Kayexalate
Administration route: Oral
Indication: Unevaluable Event

Glucophage
Dosage: total daily dose: 3000 mg unit dose: 1000 mg
Administration route: Oral
Indication: Diabetes Mellitus

Omeprazole
Dosage: total daily dose: 20 mg unit dose: 20 mg
Administration route: Oral
Indication: Duodenitis

Hemigoxine Nativelle
Dosage: total daily dose: 0.125 mg unit dose: 0.125 mg
Administration route: Oral
Indication: Atrial Fibrillation

Lasix
Dosage: total daily dose: 80 mg unit dose: 40 mg
Administration route: Oral
Indication: Essential Hypertension


Possible Lasix side effects / adverse reactions in 48 year old female

Reported by a individual with unspecified qualification from France on 2007-01-17

Patient: 48 year old female

Reactions: Rhabdomyolysis, Dizziness, Amnesia

Suspect drug(s):
Lasix
Dosage: dose: unknown dosage

Anti-Parathyroid Hormones
Indication: Hyperparathyroidism Secondary
Start date: 2006-07-01
End date: 2006-10-01

Other drugs received by patient: Sevelamer Hydrochloride; Rabeprazole Sodium; Calciprat

Possible Lasix side effects / adverse reactions in 22 year old female

Reported by a consumer/non-health professional from Brazil on 2007-01-17

Patient: 22 year old female weighing 97.0 kg (213.4 pounds)

Reactions: Vomiting, Diarrhoea, Dizziness, Muscular Weakness, Headache

Adverse event resulted in: disablity

Suspect drug(s):
Lasix

Other drugs received by patient: Tandrilax; Plasil /00041901/; Omeprazole; Levonorgestrel and Ethinyl Estradiol; Amlodipine

Possible Lasix side effects / adverse reactions in 60 year old female

Reported by a physician from Japan on 2007-01-18

Patient: 60 year old female weighing 62.8 kg (138.2 pounds)

Reactions: Pleural Effusion

Adverse event resulted in: hospitalization

Suspect drug(s):
Anafranil
Dosage: unk, unk, oral
Administration route: Oral
Indication: Depression

Lasix
Dosage: see image
Administration route: Oral
Indication: Pleural Effusion
Start date: 2006-10-26
End date: 2006-11-05

Lasix
Dosage: see image
Administration route: Oral
Indication: Pleural Effusion
Start date: 2006-11-06

Blinded Therapy (Exemestane VS Anastrazole)()
Dosage: unk, unk, oral
Administration route: Oral
Indication: Breast Cancer
Start date: 2006-11-16

Nitrazepam
Dosage: unk, unk, oral
Administration route: Oral
Indication: Depression

Almarl(arotinolol Hydrochloride)
Dosage: unk, unk, oral
Administration route: Oral
Indication: Hypertension

Loxonin /00890702(loxoprofen Sodium)
Dosage: unk, unk, oral
Administration route: Oral
Indication: Pain


Possible Lasix side effects / adverse reactions in 34 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2007-01-18

Patient: 34 year old male weighing 60.0 kg (132.0 pounds)

Reactions: Dermatitis Bullous, Thrombocytopenia

Adverse event resulted in: hospitalization

Suspect drug(s):
Triflucan
Indication: Fungal Infection
Start date: 2006-09-27
End date: 2006-10-06

Amiklin
Start date: 2006-09-27
End date: 2006-10-02

Cordarone
Administration route: Oral
Start date: 2006-09-27
End date: 2006-10-05

Lasix
Indication: Renal Failure Acute
Start date: 2006-09-27
End date: 2006-09-28

Tienam
Start date: 2006-09-27
End date: 2006-09-28

Vancomycin
Start date: 2006-09-27
End date: 2006-10-14


Possible Lasix side effects / adverse reactions in 58 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2007-01-19

Patient: 58 year old male

Reactions: Drug Interaction, Angiopathy, Renal Failure Acute, Nephropathy

Adverse event resulted in: hospitalization

Suspect drug(s):
Lasix
Dosage: daily dose: 20 milligram(s)
Administration route: Oral
Indication: Ill-Defined Disorder
End date: 2006-05-02

Lasix
Dosage: daily dose: 80 milligram(s)
Administration route: Oral
Start date: 2006-05-03
End date: 2006-05-08

Lasix
Dosage: daily dose: 40 milligram(s)
Administration route: Oral
Start date: 2006-05-09

Other drugs received by patient possibly interacting with the suspect drug:
Perindopril Erbumine
Dosage: daily dose: 4 milligram(s)
Administration route: Oral
Indication: Ill-Defined Disorder
End date: 2006-05-02

Perindopril Erbumine
Dosage: daily dose: 2 milligram(s)
Administration route: Oral
Start date: 2006-05-12

Nexen
Dosage: daily dose: unknown
Administration route: Oral
Indication: Back Pain
Start date: 2005-11-01
End date: 2006-05-02

Other drugs received by patient: Kredex; Fenofibrate

Possible Lasix side effects / adverse reactions in 81 year old female

Reported by a physician from France on 2007-01-22

Patient: 81 year old female

Reactions: Renal Failure Acute

Adverse event resulted in: hospitalization

Suspect drug(s):
Acarbose
Administration route: Oral
Indication: Unevaluable Event
End date: 2006-11-05

Lasix
Administration route: Oral
Indication: Unevaluable Event

Lasix
Administration route: Oral

Levothyroxine Sodium
Administration route: Oral
Indication: Unevaluable Event

Levothyroxine Sodium
Administration route: Oral

Novonorm
Indication: Unevaluable Event
End date: 2006-11-05

Fozitec
Administration route: Oral
Indication: Unevaluable Event
Start date: 2006-09-15
End date: 2006-11-05

Other drugs received by patient: Hydrea; Avlocardyl; Previscan; Inipomp

Possible Lasix side effects / adverse reactions in 92 year old male

Reported by a individual with unspecified qualification from Japan on 2007-01-23

Patient: 92 year old male

Reactions: Bronchopneumonia, Oedema Peripheral, Condition Aggravated, Respiratory Arrest, Respiratory Distress

Adverse event resulted in: death

Suspect drug(s):
Stromectol
Dosage: 6 mg/daily
Administration route: Oral
Indication: Acarodermatitis
Start date: 2006-10-05
End date: 2006-10-05

TAB Epinastine Hydrochloride
Dosage: 20 mg/daily
Administration route: Oral
Indication: Pruritus
Start date: 2006-10-05
End date: 2006-10-07

Lasix
Dosage: 1 tablet/daily
Administration route: Oral
Start date: 2006-10-02
End date: 2006-10-17

Other drugs received by patient: Eurax

Possible Lasix side effects / adverse reactions in 73 year old male

Reported by a health professional (non-physician/pharmacist) from Sweden on 2007-01-23

Patient: 73 year old male

Reactions: Gastrointestinal Haemorrhage, Syncope, Anaemia, Blood Creatinine Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
Atacand HCT
Dosage: 16 mg / 12.5 mg
Administration route: Oral
Indication: Essential Hypertension

Metoprolol Tartrate
Administration route: Oral

Lasix
Administration route: Oral

Aspirin
Administration route: Oral

Diklofenac
Administration route: Oral
Indication: Gout

Metformin HCL
Administration route: Oral

Other drugs received by patient: Folacin; Behepan; Lansoprazole; Glibenklamid

Possible Lasix side effects / adverse reactions in 49 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2007-01-23

Patient: 49 year old female

Reactions: Renal Failure Acute, Stevens-Johnson Syndrome

Adverse event resulted in: life threatening event

Suspect drug(s):
Dalacine
Administration route: Oral
Start date: 2006-10-12
End date: 2006-11-03

Lasix
Dosage: daily dose:1gram
Start date: 2006-10-30
End date: 2006-11-01

Oflocet
Administration route: Oral
Start date: 2006-10-13
End date: 2006-11-03

Gentamicin
Start date: 2006-10-13
End date: 2006-10-24


Possible Lasix side effects / adverse reactions in 84 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2007-01-24

Patient: 84 year old male

Reactions: Hyponatraemia, Orthostatic Hypotension

Adverse event resulted in: hospitalization

Suspect drug(s):
Xatral
Administration route: Oral
Indication: Drug USE FOR Unknown Indication
End date: 2006-10-21

Nisis
Administration route: Oral
Indication: Hypertension
End date: 2006-10-21

Aldalix
Administration route: Oral
Indication: Hypertension
End date: 2006-10-21

Amlor
Administration route: Oral
Indication: Hypertension
End date: 2006-10-21

Temesta
Administration route: Oral
Indication: Anxiety
End date: 2006-10-21

Lasix
Administration route: Oral
Indication: Hypertension
End date: 2006-10-21

Other drugs received by patient: Imodium; Creon; Cordarone; Glimepiride; Minisintrom

Possible Lasix side effects / adverse reactions in 78 year old male

Reported by a individual with unspecified qualification from Japan on 2007-01-25

Patient: 78 year old male

Reactions: Blood Alkaline Phosphatase Increased, Pruritus, Blood Lactate Dehydrogenase Increased, Erythema, Haemoglobin Decreased, RED Blood Cell Count Decreased, Cardiac Failure, Cerebral Artery Embolism, Pemphigoid, Blister

Suspect drug(s):
Lasix
Administration route: Oral
End date: 2005-06-20

Lasix
Administration route: Oral
Start date: 2005-08-03
End date: 2005-08-17

Artist

Other drugs received by patient: Micardis; Adalat; Warfarin Sodium; Luprac