Active ingredient: Furosemide - Chemisty and Biological Activity

Chemisty and Biological Activity

Chemical Formula

C12H11ClN2O5S

Chemical Name

4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid

Chemical Structure

Molecular Weight

330.745 g/mol

Physical State

Solid

Melting Point

206 oC

Water Solubility

0.006 mg/mL

Isoelectric Point

Not Available

Organisms Affected

Humans and other mammals

Phase 1 Metabolising Enzyme (1-st Step of Metabolism)

Not Available

Primary Drug Target
Name Na+/K+/2Cl- co-transporter
Gene Name SLC12A1
Synonyms Solute carrier family 12, member 1; Bumetanide-sensitive sodium-; potassium-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter
Specific Function Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume